National Institute of General Medical Sciences 5R35GM155237-03

Characterizing the effect of transcription-replication conflicts on transcription and co-transcriptional processes

This award funds research to investigate how transcription-replication conflicts affect transcription and co-transcriptional processes, focusing on RNA polymerase II speed and its role in gene expression regulation and genome stability, with implications for cancer and other diseases.

Description

Coordination between the replication and transcription process is one of the major challenges that cells face during proliferation. This project aims to understand the regulation of multiple aspects of transcriptional and co-transcriptional processes by transcription-replication conflicts and DNA damage, especially during tumorigenesis. It will explore how cells use different mechanisms to deal with conflicts at different genome regions and how these pathways are coordinated.

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