Award
National Heart, Lung, and Blood Institute 1R03HL185266-01
Elucidation of fibrotic signatures after regenerating and non-regenerating myocardial infarction
Recipient
Columbia University Health Sciences
Award Amount
$246,750.00
Ceiling
$246,750.00
Awarded
June 30, 2026
Identifier
1R03HL185266-01
Research project funded by NHLBI to study cardiac fibrosis resolution in neonatal and adult hearts using genetically modified mouse models, aiming to inform anti-fibrotic therapies for adult hearts.
Description
This project aims to use genetically modified mouse models to understand how the newborn heart dissolves its scar tissue after myocardial infarction, with potential applications for adult heart treatment. The research will generate a genetic mouse model to label the secretome of cardiac fibroblasts in vivo, profile factors elaborated by cardiac fibroblasts in uninjured adult hearts, apply this model to neonatal and adult hearts post-myocardial infarction, and compare secretory proteins between neonatal and adult hearts to understand fibrosis resolution mechanisms.