Award
National Institute of Diabetes and Digestive and Kidney Diseases 1R03DK142841-01
Deciphering the Molecular Puzzle: IMP1 Modulation of Mucus Integrity in Necrotizing Enterocolitis
Recipient
Oregon Health & Science University, Portland, OR
Award Amount
$234,000.00
Ceiling
$234,000.00
Awarded
September 04, 2025
Identifier
1R03DK142841-01
Research project investigating the role of IMP1 in mucus integrity and survival in NEC, aiming to identify new therapeutic strategies.
Description
This project aims to define the role of the RNA-binding protein IMP1 in intestinal mucus composition and survival during necrotizing enterocolitis (NEC). It uses genetic mouse models and human tissue to elucidate mechanisms of Imp1-mediated survival and mucus regulation, with the goal of identifying new therapeutic pathways.