Award
National Institute of Allergy and Infectious Diseases 1R01AI201844-01
A high throughput screen to identify broad-spectrum, mold-active antifungals
Recipient
University of Iowa, Iowa City, IA, United States
Award Amount
$582,699.00
Ceiling
$582,699.00
Awarded
July 03, 2026
Identifier
1R01AI201844-01
Research grant awarded to University of Iowa to develop a high-throughput screening assay for broad-spectrum mold-active antifungals, focusing on novel mechanisms and in vivo testing.
Description
This project aims to develop and validate a high-throughput resazurin-based screening assay against Mucor circinelloides, to identify broad-spectrum antifungal candidates, assess their bioavailability, and optimize potent molecules for in vivo testing in murine models. The goal is to identify mold-active antifungals with novel mechanisms of action by screening directly with Mucor circinelloides, to meet urgent clinical needs.