Award
National Institute on Drug Abuse 11311806
Neural mechanisms of psilocybin action in the frontal cortex
Recipient
Cornell University
Award Amount
$78,040.00
Ceiling
$78,040.00
Awarded
March 19, 2026
Identifier
11311806
Research project funded by NIDA to study how psilocybin affects brain microcircuits in the frontal cortex to understand its therapeutic potential for addiction.
Description
This project aims to determine psilocybin’s cellular and microcircuit mechanisms of action in the mouse medial frontal cortex, focusing on GABAergic interneurons and soma-dendrite coupling. The study uses two-photon calcium imaging and multi-plane calcium imaging to understand how psilocybin influences neuronal activity and coupling, which may underlie its therapeutic effects in treating neuropsychiatric illnesses such as substance use disorder.