Award
NIH Reporter #1R15DA062968-01
A Forward Genetic Screen to Identify Genes Involved in Amphetamine Action
Recipient
Florida Atlantic University, Boca Raton, FL, United States
Award Amount
$571,675.00
Ceiling
$571,675.00
Awarded
May 07, 2025
Identifier
1R15DA062968-01
A research project funded by the National Institute on Drug Abuse to identify genes involved in amphetamine action using a genetic screen in C. elegans, aiming to better understand addiction mechanisms.
Description
This project aims to identify genes involved in the action of amphetamine using a genetic approach in C. elegans, which may provide insights into addiction mechanisms in humans. The project involves a forward genetic screen using mutated strains from the Million Mutations Project to identify novel proteins that help elucidate the mechanism of action of amphetamine. The research focuses on understanding how amphetamine generates addiction by studying dopamine signaling and behavioral effects in C. elegans mutants.