Award
National Institute on Drug Abuse 11323512
VGF in the nucleus accumbens: roles in synaptic and opioid-evoked plasticity
Recipient
University of Minnesota
Award Amount
$55,114.00
Ceiling
$55,114.00
Awarded
May 21, 2026
Identifier
11323512
Research project funded by the National Institute on Drug Abuse to study the role of VGF neuropeptides in synaptic plasticity and opioid withdrawal behaviors in the nucleus accumbens, aiming to identify therapeutic targets for opioid use disorder.
Description
This proposal aims to address significant gaps in understanding how neuropeptides derived from vgf modulate synaptic plasticity in the nucleus accumbens and their role in opioid withdrawal behaviors. The project involves electrophysiology, neuroanatomical mapping, and behavioral assays to study VGF and TLQP-62 in opioid exposure and withdrawal. The work is interdisciplinary, combining physiology, mapping, and behavior to identify potential therapeutic targets for opioid use disorder.