Award
Eunice Kennedy Shriver National Institute of Child Health and Human Development 5R01HD111148-02
Does the maternal environment during viral infection and inflammation direct fetal T cell development and function?
Recipient
University of Vermont & State Agricultural College
Award Amount
$390,641.00
Ceiling
$390,641.00
Awarded
August 11, 2025
Identifier
5R01HD111148-02
Research project investigating the impact of maternal immune activation on fetal thymic gamma delta T cell development using advanced single-cell analysis and viral infection models to understand immune development and disease susceptibility.
Description
This project aims to understand how maternal infection and inflammation during pregnancy influence fetal thymic development of gamma delta T cells, and whether these effects have long-lasting impacts on gamma delta T cell function in offspring. The study will utilize a mouse model and single-cell proteogenomics workflows to delineate the effects of maternal immune activation on thymic gamma delta T cell transcriptional and epigenetic landscapes, mechanisms involved, and the impact of placental-tropic viral infections.