Award
National Institute of Neurological Disorders and Stroke 5R01NS128094-04
Interrogating a white matter degeneration-specific astrocyte reactivity state and its role in governing repair-associated microglia specification and function.
Recipient
Cedars-Sinai Medical Center, Los Angeles, CA, United States
Award Amount
$688,606.00
Ceiling
$688,606.00
Awarded
March 05, 2026
Identifier
5R01NS128094-04
The award funds research to understand astrocyte-microglia interactions in white matter degeneration and repair, aiming to inform new therapies for CNS injury and neurodegenerative diseases.
Description
This research aims to dissect molecular pathways of astrocyte-microglia interaction that govern pro-restorative CNS innate immune responses to white matter degeneration, focusing on a newly identified mechanism of intercellular communication involving a subpopulation of white matter degeneration-reactive astrocytes. The study will utilize transgenic mouse models, single-nucleus RNA-Sequencing (snRNA-Seq), and snATAC-Seq to analyze astrocyte reactivity and microglia function over time, with the goal of understanding how these interactions shape CNS innate immune responses and facilitate white matter repair.