Award
NIH Reporter #5R01AI159677-05
Development of human adaptive immunity to Staphylococcus aureus
Recipient
Washington University, Saint Louis, MO
Award Amount
$640,665.00
Ceiling
$640,665.00
Awarded
April 17, 2025
Identifier
5R01AI159677-05
NIH-funded research project by Washington University to study human adaptive immunity to Staphylococcus aureus, aiming to inform vaccine development to combat infections and antibiotic resistance.
Description
Research project investigating the human adaptive immune response to Staphylococcus aureus during development and early childhood to inform vaccine design and implementation. The study focuses on immune responses to S. aureus, including the role of α-toxin (Hla), immune development in children, T cell responses characterized by CyTOF, and antibody responses to virulence factors, supporting the development of a universal vaccine.