Award
National Cancer Institute OTA-24-001
MATCHMAKERS - Solving T-cell receptor recognition and design via integrated high-throughput screening and structural, functional and computational approaches
Recipient
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
Award Amount
$327,770.00
Ceiling
$327,770.00
Awarded
May 01, 2026
Identifier
OTA-24-001
Award for a project to develop machine learning and structural biology methods to predict and design T-cell receptor recognition of tumor antigens, funded by the National Cancer Institute with a budget of $327,770 for FY 2026.
Description
The project aims to develop predictors of TCR-antigen recognition using machine learning, structural biology, and immunology. It is spread across four work packages focusing on data generation, molecular engineering, structural analysis, and AI-based prediction. The project duration is from May 1, 2024, to April 30, 2027, with a total budget of $327,770 for FY 2026. The project focuses on understanding T cell receptor recognition of tumor antigens presented by MHCs and aims to combine machine learning with structural and functional datasets to predict and design TCR interactions. It involves collaboration with researchers in immunology, structural biology, and computation and is funded by the National Cancer Institute, part of NIH.