Award
National Heart, Lung, and Blood Institute 5R01HL168493-03
Genetic Predisposition to Myocardial Infarction in Patients with Coronary Artery Disease
Recipient
University of California Los Angeles
Award Amount
$685,633.00
Ceiling
$685,633.00
Awarded
July 06, 2026
Identifier
5R01HL168493-03
Research project funded by the National Heart Lung and Blood Institute to investigate genetic factors that increase the risk of myocardial infarction in patients with coronary artery disease, aiming to discover novel therapeutic targets.
Description
This project aims to elucidate the genetic basis of myocardial infarction (MI) among coronary artery disease (CAD) patients, identify candidate causal genes, and validate findings using mouse models to develop targeted therapies. The study hypothesizes that certain genes predispose more strongly to MI than CAD alone, performing large-scale meta-analyses, whole-exome analyses, and functional validation in mouse models to identify and prioritize MI-specific genetic risk factors.