Award
NIH Reporter #1R01AR085636-01A1
Investigating clinical heterogeneity in immune checkpoint inhibitor-induced inflammatory arthritis
Recipient
Johns Hopkins University, Baltimore, MD
Award Amount
$569,402.00
Ceiling
$569,402.00
Awarded
July 06, 2026
Identifier
1R01AR085636-01A1
A research project funded by NIAMS to study the clinical heterogeneity of immune checkpoint inhibitor-induced inflammatory arthritis using multicenter cohort data, ultrasound imaging, cytokine biomarkers, and predictive modeling.
Description
This project addresses a rapidly increasing health condition, immune checkpoint inhibitor-induced inflammatory arthritis. It aims to understand heterogeneity in disease trajectories, treatment responses, targeted tissues, and immune responses. The study will utilize the first prospective USA multicenter cohort of rheumatic irAEs, the RADIOS cohort, to evaluate clinical features, disease activity, tissue involvement via ultrasound, cytokine biomarkers, and predictive models for clinical outcomes.