Award
National Institute of Allergy and Infectious Diseases 5R01AI170832-04
Toll-like receptor control of endocytic antigen cross-presentation
Recipient
WEILL MEDICAL COLL OF CORNELL UNIV, NY, UNITED STATES
Award Amount
$675,627.00
Ceiling
$675,627.00
Awarded
June 03, 2026
Identifier
5R01AI170832-04
Research project funded by NIAID to study TLR regulation of antigen cross-presentation to improve CD8 T cell vaccine responses against viruses like HIV, Ebola, and Dengue.
Description
The project aims to investigate Toll-like receptor (TLR) regulation of endocytic antigen cross-presentation to enhance CD8 T cell vaccine responses against intracellular pathogens such as HIV, Ebola, and Dengue viruses. The study focuses on the mechanisms of MHC-I trafficking and TLR signaling pathways involved in cross-presentation.