NIH Reporter #5U19AI131471-10

Administrative Core

NIH grant awarded to Duke University for the Administrative Core project focusing on immune tolerance induction regimens and biomarker development in nonhuman primate transplantation models.

Description

The purpose of this Collaborative Program is to bring together investigators focusing on a coordinated and synergistic strategy within the overarching goals of the Nonhuman Primate Transplantation Tolerance Cooperative Study Group (NHPCSG), including: (1) development of novel tolerance induction regimens; (2) evaluation of the preclinical safety and efficacy of existing and newly developed candidate immune tolerance induction regimens; (3) development and validation of biomarkers for the induction, maintenance and/or loss of immune tolerance or for the prediction of graft rejection; and (4) elucidation of the mechanisms underlying the induction, maintenance, and/or loss of tolerance in NHP allograft models of islet, kidney, heart, and/or lung transplantation. The core will manage fiscal and other resources, facilitate interactions and communication, ensure timely progress, and ensure adherence to NIH regulations.

View original record