National Institute of Allergy and Infectious Diseases 5R00AI159620-04

Deciphering the pathogenesis of an enteric pathogen in neonatal and immunodeficient mice

This award supports research using neonatal and immunodeficient mice to study the pathogenesis and immune response to enteric and systemic infections caused by Citrobacter rodentium and Salmonella Typhimurium, aiming to improve treatment strategies for affected children and immunocompromised patients.

Description

Project narrative: Infectious diarrhea and bacteremia remain serious public health concerns in children and immunocompromised adults, but the lack of animal models that accurately resemble the infection observed in these patients have limited our understanding of the disease. We propose the use of novel neonatal and immunodeficient mice to study the pathogenesis and immune response during enteric and systemic infection by Citrobacter rodentium and Salmonella enterica serovar Typhimurium. These studies have the potential for a major impact on the design of better strategies to treat these conditions in children and patients with impaired adaptive immunity.

View original record