Award
NIH Reporter #5K08GM152844-04
Unraveling how Lipophilic Modulators Alter pLGIC Function via Interactions with the M4 Transmembrane Helix
Recipient
Washington University, Saint Louis, MO, United States
Award Amount
$185,953.00
Ceiling
$185,953.00
Awarded
August 04, 2026
Identifier
5K08GM152844-04
NIH grant awarded to Washington University for research on how lipophilic modulators affect pentameric ligand-gated ion channels via the M4 transmembrane helix, using computational biophysics to advance drug discovery in anesthesia.
Description
This NIH grant supports research in molecular biophysics, drug discovery, and anesthesiology. The project involves computational modeling, free energy calculations, and electrophysiology techniques. The candidate will work under expert mentors and an advisory committee to develop skills for an independent research career.