Award
NIH Reporter #4UH3CA290517-03
Immune determinants modulating cancer development in Lynch Syndrome
Recipient
ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
Award Amount
$818,489.00
Ceiling
$818,489.00
Awarded
July 15, 2026
Identifier
4UH3CA290517-03
Research project focused on identifying immune factors and neoantigens involved in cancer development in Lynch Syndrome to develop preventive strategies against colorectal cancer.
Description
This project investigates the immune determinants that influence cancer development in Lynch Syndrome. It aims to map neoantigens in pre-cancerous colorectal polyps, identify TCRs recognizing these neoantigens, and analyze the tumor microenvironment to find targets for prevention/interception strategies.