Award
National Institute on Alcohol Abuse and Alcoholism 5R01AA029686-04
CB1-mediated signaling in developmental ethanol effects
Recipient
Nathan S. Kline Institute for Psych Res
Award Amount
$448,832.00
Ceiling
$448,832.00
Awarded
June 16, 2026
Identifier
5R01AA029686-04
The award supports research on the molecular mechanisms by which prenatal alcohol exposure causes persistent neurobehavioral impairments, focusing on CB1 signaling and histone methylation in specific neuronal types to identify therapeutic targets for fetal alcohol spectrum disorder.
Description
This project aims to elucidate the epigenetic and synaptic mechanisms by which prenatal alcohol exposure affects brain development, with potential implications for therapeutic strategies. It investigates how enhanced CB1 activity and histone methylation caused by postnatal alcohol exposure lead to aberrant synaptic gene expression and behavioral deficits, using cell-type-specific technologies and conditional gene deletions in mice models.