Award
National Institute of General Medical Sciences 5R35GM122559-08
Discovery of Antibiotics from Soil Microbiomes Using Metagenomics
Recipient
Rockefeller University
Award Amount
$678,000.00
Ceiling
$678,000.00
Awarded
August 15, 2025
Identifier
5R35GM122559-08
This award funds research to discover new antibiotics from soil microbiomes using metagenomic techniques to combat multidrug-resistant pathogens.
Description
The project aims to develop culture-independent (metagenomic) approaches for identifying novel natural products encoded in soil metagenomes, focusing on discovering new antibiotics effective against multidrug-resistant pathogens. The work involves extracting DNA directly from environmental samples, cloning into easily cultured bacteria, and using sequence-based and functional screening methods to identify bioactive small molecules.