Award
National Institute on Drug Abuse 7U01DA050243-05
A reduced Complexity Cross in BALB/c substrains to identify the genetic basis of oxycodone dependence phenotypes
Recipient
Northeastern University, Boston, MA
Award Amount
$587,914.00
Ceiling
$587,914.00
Awarded
July 24, 2024
Identifier
7U01DA050243-05
This award funds research to discover genetic and molecular bases of opioid addiction traits using mouse models, aiming to identify novel genetic factors and biological pathways involved in oxycodone dependence.
Description
The project aims to identify genetic factors underlying oxycodone dependence using mouse models and advanced genetic techniques including QTL mapping, gene expression analysis, and CRISPR validation. The study focuses on opioid addiction-relevant traits at two stages of opioid dependence following oxycodone administration in BALB/c substrains.