Award
NIH Reporter #5R21DE033457-02
The role of Fusobacterium nucleatum and Candida albicans interkingdom interactions in promoting OSCC
Recipient
National Institute of Dental and Craniofacial Research (NIDCR)
Award Amount
$205,517.00
Ceiling
$205,517.00
Awarded
December 18, 2024
Identifier
5R21DE033457-02
The awarded project investigates how interactions between Candida albicans and Fusobacterium nucleatum contribute to oral squamous cell carcinoma, using various laboratory and animal experiments to understand microbial roles in cancer development.
Description
This project aims to explore the potential role of interkingdom microbial interactions in oral squamous cell carcinoma (OSCC), focusing on the interaction between Candida albicans and Fusobacterium nucleatum, and their contribution to carcinogenesis through mechanisms involving coaggregation and upregulation of oncogenes such as INHBA.