Award
National Institute of Allergy and Infectious Diseases 5R01AI154777-05
Novel Antimalarials from Fungi
Recipient
University of Central Florida
Award Amount
$754,049.00
Ceiling
$754,049.00
Awarded
April 15, 2024
Identifier
5R01AI154777-05
The award supports research to identify new antimalarial compounds from fungi to combat drug-resistant malaria, involving screening, compound identification, and target validation.
Description
This project aims to discover novel antimalarial compounds from fungal secondary metabolites, which are underexplored for this purpose. The research involves screening a library of 10,000 fungal extracts, dereplicating bioactive extracts, identifying and characterizing active compounds, and validating their targets using genome editing techniques.