Award
NIH Reporter #5R01DE034357-02
The role of primary cilia and C2cd3 in craniofacial skeletogenesis
Recipient
Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA
Award Amount
$642,392.00
Ceiling
$642,392.00
Awarded
June 18, 2026
Identifier
5R01DE034357-02
Research project funded by NIDCR to study the role of primary cilia and C2cd3 in craniofacial skeletal development and ciliopathies, focusing on OFD14 disease mechanisms and potential therapies.
Description
This project investigates the role of primary cilia and C2cd3 in craniofacial skeletal development, with potential therapeutic implications for ciliopathies. It aims to elucidate the cellular and molecular etiology of OFD14 and identify therapeutic intervention points using knockdown and conditional knockout transgenic murine lines and human induced pluripotent stem cells.