Award
NIH Reporter #1R01HL188233-01
The role of mitochondrial calcium uniporter in platelet function and thrombosis
Recipient
Washington University, Saint Louis, MO
Award Amount
$803,772.00
Ceiling
$803,772.00
Awarded
August 13, 2026
Identifier
1R01HL188233-01
Research project funded by the National Heart Lung and Blood Institute to study the role of mitochondrial calcium uniporter in platelet function and thrombosis, aiming to develop novel therapies for ischemic stroke.
Description
This project aims to determine how mitochondrial calcium uniporter (MCU) regulates platelet activation, procoagulant platelet formation, and platelet-neutrophil interactions, and whether targeting MCU improves stroke outcomes. It involves clinical, in vitro, and in vivo approaches, sequencing, and microscopy techniques to elucidate the role of mitochondrial calcium flux in platelet activation and its potential as a therapeutic target in ischemic stroke.