Award
NIH Reporter #1ZIADK052034-19
What determines the location of meiotic crossovers in the mammalian genome?
Recipient
National Institute of Diabetes and Digestive and Kidney Diseases
Award Amount
$2,097,315.00
Ceiling
$2,097,315.00
Awarded
October 04, 2023
Identifier
1ZIADK052034-19
Research project funded by the National Institute of Diabetes and Digestive and Kidney Diseases to study the determinants of meiotic crossover locations in mammals using genomic and chromatin analysis techniques.
Description
This project involves advanced genomic and chromatin analysis techniques to study meiotic recombination. The research explores the role of PRDM9, chromatin modifications, and replication timing in crossover determination. It includes mapping hotspots, analyzing structural features, and studying chromatin dynamics during spermatogenesis.