Award
NIH Reporter #5R01CA248930-06
TRIM37 is a genetic determinant of racial disparity in metastatic TNBC patients
Recipient
University of California at Davis
Award Amount
$466,575.00
Ceiling
$466,575.00
Awarded
March 13, 2025
Identifier
5R01CA248930-06
Award to University of California at Davis to study TRIM37 genetic variants linked to racial disparities in metastatic TNBC and develop targeted therapies.
Description
This project aims to demonstrate that TRIM37 is a genetic variant associated with high risk of metastatic triple negative breast cancer (TNBC) in African American women and to generate proof-of-concept data for treating metastatic TNBC using TRIM37-specific antisense oligonucleotides and investigational clinical anti-FOLR1 antibody-guided nanoparticles. The study focuses on racial disparities in TNBC and explores targeted therapies based on genetic variants of TRIM37.