Award
NIH Reporter #5R35CA304457-02
Understanding and Targeting Aberrant RNA Splicing in Leukemia
Recipient
Sloan-Kettering Institute for Research
Award Amount
$1,015,176.00
Ceiling
$1,015,176.00
Awarded
July 29, 2026
Identifier
5R35CA304457-02
Award supports research on RNA splicing mutations in leukemia to develop targeted therapies, focusing on neo-antigens, mis-splicing factors, and unique protein isoforms in mutant cells.
Description
This R35 award enables research to identify mechanisms by which mutations in RNA splicing machinery drive myeloid and lymphoid leukemias and to develop novel therapies targeting these mutations. The research focuses on therapeutically targetable neo-antigens, trans factors required for mis-splicing, and unique protein isoforms in splicing factor mutant cells, utilizing transcriptomic, immunogenomic, and chemoproteomic approaches.