Award
National Institute of Allergy and Infectious Diseases 5R16AI167814-04
Redefining Fermentation Parameters in Natural Products Drug Discovery
Recipient
EASTERN MICHIGAN UNIVERSITY
Award Amount
$150,000.00
Ceiling
$150,000.00
Awarded
August 01, 2025
Identifier
5R16AI167814-04
The award supports research to accelerate discovery of novel antibiotics by optimizing fermentation conditions to activate silent gene clusters in microbes, addressing the urgent need for new treatments against antibiotic-resistant pathogens.
Description
This project aims to develop reproducible fermentation conditions to stimulate silent antibiotic production, focusing on mixed-culture fermentation and co-culture techniques to identify novel antibiotics effective against high-priority pathogens. The research includes optimizing fermentation conditions to induce silent biosynthetic gene clusters (BGCs) for antibiotic production and characterizing bioactive compounds.