Award
National Cancer Institute 5R01CA294651-02
Deoxyuridine Contamination and Innate Immune Signaling
Recipient
University of Pittsburgh at Pittsburgh, PA, United States
Award Amount
$644,234.00
Ceiling
$644,234.00
Awarded
April 01, 2026
Identifier
5R01CA294651-02
Research project studying how deoxyuridine contamination affects innate immune signaling in cancer treatments involving ATR inhibitors and antimetabolites.
Description
This project investigates the impact of deoxyuridine (dU) contamination on innate immune responses, particularly in the context of chemotherapy and DNA replication. It explores how ATR inhibitors increase dU incorporation into DNA and the subsequent immune signaling pathways involved, with implications for cancer treatment efficacy.