NIH Reporter #5R35GM155237-03

Characterizing the effect of transcription-replication conflicts on transcription and co-transcriptional processes

This NIH-funded project at Vanderbilt University studies how transcription-replication conflicts affect transcription and co-transcriptional processes, focusing on RNA polymerase II speed and conflict resolution mechanisms, with implications for cancer and aging therapies.

Description

Coordination between the replication and transcription process is one of the major challenges that cells face during proliferation. This project aims to understand the regulation of multiple aspects of transcriptional and co-transcriptional processes by transcription-replication conflicts and DNA damage, especially during tumorigenesis. It focuses on the effect of transcription-replication conflicts on transcription, the role and significance of RNA polymerase II speed in maintaining cellular fitness, and the mechanistic role of the Integrator complex in conflicts. The work will provide insights into the regulation of transcription and replication, potentially leading to novel therapeutic strategies for aging and cancer.

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