# NIH Reporter #1R21AG104259-01

A[18F]3F4AP PET measure of myelin/axonal integrity in aging and Alzheimer's disease

**Recipient:** Not specified

**Award Amount:** $538,456.00
**Ceiling:** $538,456.00

**Awarded:** September 09, 2026

**Identifier:** 1R21AG104259-01

Award for research project to measure myelin and axonal integrity in aging and Alzheimer's disease using PET and MRI imaging techniques.

### Description

This project involves evaluating MRI diffusion tensor imaging and [18F]3F4AP PET to understand myelin integrity in aging and Alzheimer's disease. The study will include 28 participants with various cognitive statuses, undergoing PET scans, MRI, and cognitive testing. The goal is to optimize PET quantification and identify changes in myelin integrity related to AD and CVD pathology.

[View original record](https://reporter.nih.gov/search/IgE1H2ioLUOz0qmA4MDg0Q/project-details/11442811)