Award
NIH Reporter #2R01DK124115-05A1
Mitochondria mediated intercellular metabolic coupling in bone marrow regeneration
Recipient
Dana-Farber Cancer Institute, Boston, MA, United States
Award Amount
$866,588.00
Ceiling
$866,588.00
Awarded
May 07, 2026
Identifier
2R01DK124115-05A1
This award funds research to understand how mitochondrial activity and transfer between hematopoietic stem cells and bone marrow mesenchymal stem cells regulate bone marrow regeneration, aiming to improve stem cell transplantation protocols.
Description
Hematopoietic stem cell (HSC) transplantation after conditioning is widely used in the clinic to treat pathological mutations in the lympho-hematopoietic system. The mechanisms of interaction between the bone marrow (BM) microenvironment (ME) and transplanted HSC remain a mystery. Understanding these mechanisms, especially how Cx43 regulates mitochondrial activity and transfer between HSCs and BM mesenchymal stem cells (MSCs), could significantly improve HSCT protocols and reduce reliance on myeloablative conditioning.