Award
National Institute on Aging 5R01AG056569-09
Recognition of Abeta monomeric helix
Recipient
University of South Florida
Award Amount
$580,493.00
Ceiling
$580,493.00
Awarded
December 23, 2025
Identifier
5R01AG056569-09
The award supports research to develop helical peptidomimetics that bind and stabilize monomeric helical Aβ to prevent and disrupt aggregation, aiming to create new treatments for Alzheimer's Disease.
Description
This project focuses on designing helical peptidomimetics to target and disrupt Aβ aggregation, with potential applications to other amyloid diseases. It aims to develop effective molecular probes and therapeutics for Alzheimer's Disease (AD). The research is significant as it offers a novel mechanism for AD treatment by applying rational design of foldameric compounds targeting Aβ surface, extendable to other amyloid diseases.