Award
National Institute of General Medical Sciences 5K99GM155323-02
Functional Convergence at the Host-Virus Interface
Recipient
Utah State Higher Education System--University of Utah
Award Amount
$125,000.00
Ceiling
$125,000.00
Awarded
August 11, 2025
Identifier
5K99GM155323-02
This NIH grant supports research on host-virus protein interactions, aiming to understand antiviral protein evolution and functional convergence through structural homology and computational biology.
Description
The project focuses on using structural homology screens to identify and classify antiviral proteins in biodiverse genomes, as well as anti-immune genes in diverse viruses. It studies protein families that have diverged to serve distinct functions, with some evolving to become antiviral proteins. This multidisciplinary evolution-driven study of infection biology offers insights into functional convergence and protein evolution.