National Institute of Allergy and Infectious Diseases 5R21AI186057-02

Lung-innervating nociceptor sensory neurons suppresses Ly6chi monocyte responses to promote pneumonic sepsis

NIH awarded a research grant to study how lung-innervating nociceptor sensory neurons affect immune responses in pneumonic sepsis, aiming to find new therapeutic targets against Gram-negative bacterial pneumonia and sepsis.

Description

This NIH-funded research project aims to understand the role of nociceptor sensory neurons and neuropeptide signaling in host defense against Gram-negative bacterial pneumonia and sepsis. The project involves in vivo and in vitro studies, neuronal manipulation, and neuroimmune interaction analysis. The goal is to identify novel mechanisms and therapeutic targets to combat pneumonic sepsis caused by carbapenem-resistant Klebsiella pneumoniae.

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