Award
NIH Reporter #3R35GM134842-07S1
Reconstitution and biophysical study of chromosome segregation machinery
Recipient
University of Washington
Award Amount
$91,433.00
Ceiling
$91,433.00
Awarded
September 04, 2026
Identifier
3R35GM134842-07S1
This award funds research to reconstitute and study the mitotic spindle's chromosome segregation machinery, focusing on kinetochore-microtubule interactions to understand mechanisms ensuring accurate chromosome segregation during cell division.
Description
During cell division, duplicated chromosomes are organized and separated by an exquisite molecular machine called the mitotic spindle. To uncover how the spindle works, the project involves reconstituting its activities using isolated components and developing biophysical tools to directly manipulate and track their dynamics at the single molecule level. The research aims to understand kinetochore behaviors, including asymmetric grip strength on microtubules, which promotes proper chromosome attachment and segregation.