Award
National Institute of Allergy and Infectious Diseases (NIAID) 5R01AI192378-02
Persistent Immunogenicity of IDLV delivering Gag and membrane tethered HIV-1 Envelope Trimers
Recipient
Duke University
Award Amount
$799,422.00
Ceiling
$799,422.00
Awarded
July 06, 2026
Identifier
5R01AI192378-02
The award supports development of a multi-antigen HIV vaccine using IDLV vectors to induce durable immune responses, with studies in rhesus macaques to evaluate vaccine efficacy and durability.
Description
This project will develop a novel multi-antigen vaccine based on optimized non-integrating lentiviral vectors to induce persistent immune responses against HIV-1. These vectors will durably express both Gag and a stabilized membrane-tethered HIV-1 envelope trimer to promote broad, persistent, and protective immune responses. The study involves immune response analysis in rhesus macaques, combining transcriptomics with flow cytometry, BCR sequencing, and immune cell landscape studies to understand vaccine durability and efficacy.