Award
National Institute on Drug Abuse 1R01DA065476-01A1
Role of microglial ferritinophagy in HIV and cocaine-mediated neuroinflammation
Recipient
UNIVERSITY OF NEBRASKA MEDICAL CENTER
Award Amount
$544,256.00
Ceiling
$544,256.00
Awarded
May 13, 2026
Identifier
1R01DA065476-01A1
Research project funded by the National Institute on Drug Abuse to study the disruption of ferritinophagy in brain immune cells caused by HIV and cocaine, testing a therapeutic molecule C381 to reduce neuroinflammation and cognitive damage.
Description
This project investigates how HIV proteins, lifelong cART adherence, and cocaine misuse damage brain immune cells by disrupting ferritinophagy, a process that controls iron balance. The study tests a small molecule, C381, which restores lysosomal function, aiming to reduce brain inflammation and protect memory and cognition in people living with HIV who also use stimulants.