Award
National Institute of Mental Health 5R01MH139940-02
Pathophysiological mechanisms of cannabidiol in stress regulation
Recipient
ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
Award Amount
$743,561.00
Ceiling
$743,561.00
Awarded
January 27, 2026
Identifier
5R01MH139940-02
NIH grant awarded to ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI to study how cannabidiol affects stress regulation in young adults with early life adversity through clinical trials and neuroimaging.
Description
This project aims to investigate the mechanisms of cannabidiol (CBD) in modulating stress responses, especially in young adults with early life adversity (ELA), using neuroimaging and clinical trials. It involves a double-blind, randomized, placebo-controlled trial with oral CBD (400 mg) versus placebo to evaluate neural, endocrine, and behavioral effects of CBD on stress regulation.