Award
University of California San Diego 5DP5OD031878-05
High-throughput imaging of 3D chromatin regulation events in the nervous system
Recipient
University of California, San Diego
Award Amount
$395,000.00
Ceiling
$395,000.00
Awarded
August 20, 2025
Identifier
5DP5OD031878-05
This award supports the development of a multiplexed imaging and synthetic biology platform to understand chromatin regulation and gene expression in the peripheral olfactory system, focusing on 3D chromatin structure and neuronal subtype control.
Description
The project aims to develop an imaging platform that can measure the 3D structure of DNA, RNA expression, and interaction with structural proteins simultaneously in the peripheral olfactory system. It also uses high-throughput synthetic biology to dissect gene regulatory element-promoter interactions and control receptor neuron subpopulations.