Award
National Institute of Arthritis and Musculoskeletal and Skin Diseases 5P50AR080596-04
The role of the osteocyte in responses to osteoporosis anabolic treatment in humans and mice
Recipient
Massachusetts General Hospital
Award Amount
$340,976.00
Ceiling
$340,976.00
Awarded
December 12, 2025
Identifier
5P50AR080596-04
Research project funded by NIAMS to study osteocyte responses to osteoporosis anabolic treatments in humans and mice, aiming to improve therapy efficacy and safety.
Description
This project focuses on understanding the anabolic action and waning effects over time of osteoporosis treatments PTH1-34 and sclerostin antibody in humans and mice by studying the role of osteocytes in bone remodeling and mass. It aims to reveal novel therapeutic mechanisms and targets to improve the efficacy and safety of anabolic therapies for osteoporosis.