Award
NIH Reporter #5R21MH136489-02
Sex dependent dysregulation of parvalbumin interneurons as a pathway to Autism Spectrum Disorder
Recipient
FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH, MANHASSET, NY, UNITED STATES
Award Amount
$209,375.00
Ceiling
$209,375.00
Awarded
August 06, 2025
Identifier
5R21MH136489-02
Research on how maternal anti-Caspr2 antibodies affect interneuron development differently by sex, potentially contributing to Autism Spectrum Disorder, using a mouse model.
Description
This project investigates the sex-dependent effects of maternal anti-Caspr2 antibodies on interneuron development and their potential role in ASD, utilizing a mouse model with in utero exposure and electrophysiological assessments.