Award
National Institute of Arthritis and Musculoskeletal and Skin Diseases 1R01AR086588-01A1
Cartilage targeting exosomes for OA gene therapy and pain treatment
Recipient
Northeastern University, Boston, MA, United States
Award Amount
$652,195.00
Ceiling
$652,195.00
Awarded
June 19, 2026
Identifier
1R01AR086588-01A1
This NIH grant funds research to develop engineered cartilage-targeting exosomes for gene therapy to treat osteoarthritis by delivering therapeutic genetic material to cartilage and related tissues, aiming to modify disease progression and relieve pain.
Description
Gene therapy has the potential to facilitate targeted expression of therapeutic proteins to promote cartilage regeneration in osteoarthritis (OA). The project aims to engineer surface-modified cartilage-targeting MSC exosomes as non-viral carriers for gene therapy to deliver IL-1RA mRNA and NaV1.8 siRNA to modify disease progression and provide long-term pain relief.