Award
NIH Reporter #5R01CA305375-02
Pre-synaptic events in homologous recombination and maintenance of genomic stability
Recipient
Saint Louis University
Award Amount
$504,207.00
Ceiling
$504,207.00
Awarded
August 13, 2026
Identifier
5R01CA305375-02
Research project funded by the National Cancer Institute to study the molecular mechanisms of DNA repair via homologous recombination, focusing on Rad52, Rad51 paralogs, and BRCA2 to maintain genomic stability and prevent cancer.
Description
This project investigates the molecular mechanisms of DNA repair processes critical for maintaining genomic stability and preventing cancer development. It aims to decipher how Rad52 recognizes ss-dsDNA junctions, how Rad51 paralogs promote filament formation, and how these properties are enacted in human BRCA2 using techniques such as FRET microscopy, structural mass spectrometry, and C-trap analysis to understand double-stranded DNA break repair mechanisms.