Award
National Heart, Lung, and Blood Institute 5R01HL175155-02
Defining targetable vulnerabilities in UBA1-mutated VEXAS HSCs for clonal eradication
Recipient
National Heart Lung and Blood Institute (NHLBI), NIH
Award Amount
$747,490.00
Ceiling
$747,490.00
Awarded
February 26, 2026
Identifier
5R01HL175155-02
Research project awarded by NHLBI, NIH to study UBA1-mutated VEXAS syndrome using advanced single-cell and spatial analysis techniques to find therapeutic targets.
Description
The project focuses on exploring the mechanisms of VEXAS syndrome caused by UBA1 mutations. The research involves single-cell and spatial analysis, genotype-aware single-cell multi-omics, and spatial transcriptomics. The goal is to identify potential targets for precision therapies.