# NIH Reporter #5I01BX002378-11

Mechanisms driving airway inflammation in chronic lung disease

**Recipient:** Veterans Health Administration

**Awarded:** October 27, 2026

**Identifier:** 5I01BX002378-11

The project studies mechanisms of persistent airway inflammation and COPD progression, including the roles of epithelial NF-κB, T lymphocytes, and dendritic cell subsets.

### Description

Investigates how impairment of small-airway mucosal immunity leads to persistent innate and adaptive immune activation, airway remodeling, and emphysema in COPD.

[View original record](https://reporter.nih.gov/search/7U_RDKopbE--cH-2OrGcnA/project-details/11610658)