Award
National Heart, Lung, and Blood Institute 5P01HL160557-03
Sex and Leptin control of endothelial cell glycolysis and redox balance in Type 1 Diabetes
Recipient
Augusta University, Augusta, GA, United States
Award Amount
$505,582.00
Ceiling
$505,582.00
Awarded
May 13, 2026
Identifier
5P01HL160557-03
This NIH-funded project studies how endothelial cell glycolysis and leptin signaling affect vascular redox balance and vasorelaxation in type 1 diabetes, with a focus on sex differences and therapeutic targets.
Description
The project aims to delineate the molecular mechanisms whereby endothelial cell (EC) bioenergetics, especially glycolysis, regulate vascular redox status and vasorelaxation in physiological and pathological conditions, focusing on type 1 diabetes (T1D). It investigates how EC glycolysis, regulated by PFKFB3 and influenced by leptin, impacts endothelial dysfunction, a precursor to vascular complications in T1D. The study explores sex-specific mechanisms, including the roles of sex hormones and chromosomes, and the potential of targeting the leptin-PFKFB3-Nox1 axis for therapeutic intervention.