Award
National Institute on Alcohol Abuse and Alcoholism 5R01AA029072-04
Circadian and mitochondrial dysfunction in alcohol-related liver disease
Recipient
University of Alabama at Birmingham, Birmingham, AL, United States
Award Amount
$457,851.00
Ceiling
$457,851.00
Awarded
March 31, 2026
Identifier
5R01AA029072-04
The award funds research on the impact of chronic alcohol consumption on liver circadian rhythms and mitochondrial function, aiming to uncover mechanisms of alcohol-related liver disease and facilitate new therapeutic developments.
Description
This project investigates how heavy alcohol drinking disrupts the molecular circadian clock in liver cells, impairing mitochondrial bioenergetic function and contributing to alcohol-related liver disease (ALD). The research aims to understand the molecular mechanisms of mitochondrial damage caused by chronic alcohol use and the role of circadian rhythms in ALD pathogenesis, with the goal of advancing drug discovery for treatment.