Award
National Institute on Aging 5R01AG081419-04
Role of the microglial immune-oxysterol 25-hydroxycholesterol in mediating neuroinflammation and neurodegeneration in the P301S tau transgenic mouse model of Alzheimer's disease
Recipient
Washington University, Saint Louis, MO
Award Amount
$445,870.00
Ceiling
$445,870.00
Awarded
March 20, 2026
Identifier
5R01AG081419-04
NIH awarded a research grant to Washington University to study the role of 25-hydroxycholesterol in neuroinflammation and neurodegeneration in Alzheimer's disease, with a project duration from 2023 to 2028.
Description
This NIH research grant focuses on studying the role of the immune-oxysterol 25-hydroxycholesterol in microglia-mediated neuroinflammation and neurodegeneration related to Alzheimer's disease using the P301S tau transgenic mouse model. The project aims to elucidate mechanisms potentially leading to novel therapeutic strategies.